Event Date
Event Date
We report a full-field swept-source optical coherence tomography (FF-SS-OCT) system with a ~ 20 million A-scan/s rate for the in vivo structural and functional imaging of the mouse retina. The FF-SS-OCT, configured as an on-axis Mach-Zehnder interferometer, employs a tunable wavelength source and a high-speed 2D CMOS camera. Optimized coherent illumination and detection strategies are implemented for an efficient full-field imaging of the mouse retina. The light-evoked experiments (Optoretinography-ORG) are performed using a single-flash stimulus to bleach controlled fractions of rhodopsin in individual experiments. Serial OCT volume acquisition facilitates the quantitative assessment of relative shifts in outer retinal layer positions and changes in the backscattering intensity post-stimuli.
Presenter
Univ. of California, Davis (United States)
Dr.Ratheesh K. Meleppat received his Ph.D. in optical imaging from Nanyang Technological University (NTU) Singapore. He completed his Bachelor’s degree (B.Tech) in Electronics & Communication Engineering from University of Calicut, India and Master’s Degree (M.Tech) in Optoelectronics & Optical communication from the University of Kerala, India. Dr.Ratheesh is currently a Research Scientist at University of California Davis (UC DAVIS),USA. His research investigates the novel cutting-edge biomedical instrumentation and image processing schemes for the advanced ophthalmic imaging and applications. The primary focus on the instrumentation research is the development and use of imaging technologies such as Optical Coherence Tomography (OCT), OCT Angiography (OCTA), Scanning Laser Ophthalmoscope (SLO), Multispectral Fluorescent microscopy, Adaptive Optics (AO), and their combinations to study the retina noninvasively at the cellular level.