Interferometric Diffuse Optical Spectroscopy (iDOS)
Combining interferometric near-infrared spectroscopy (iNIRS) and interferometric diffusing wave spectroscopy (iDWS), will advance novel Interferometric Diffuse Optical Spectroscopy (iDOS) technology for continuous and non-invasive blood flow monitoring in critical clinical scenarios.
Diffuse Optical Spectroscopy (DOS) monitors deep tissue physiology with multiply scattered near-infrared light. Although use of non-ionizing near-infrared radiation to assess deep tissue physiology seems simple, powerful, and appealing, superficial tissue contamination and quantitative inaccuracy plague DOS. Benefitting from low cost and high throughput, continuous wave (CW) NIRS with caveats, can measure brain activity. But, in the clinical realm, low depth specificity, poor quantification and accuracy, and the ambiguity of tissue oxygenation measures have limited its use. Scenarios like traumatic brain injury (TBI), stroke, reconstructive surgery, and perinatal obstetrics, could benefit from the non-invasive optical imaging and monitoring of DOS.
Dr. Srinivasan has developed a paradigm-shifting approach, interferometric diffuse optical spectroscopy (iDOS), which surmounts barriers to blood flowmetry by combining interferometric Diffusing Wave Spectroscopy (iDWS) and interferometric NIRS (iNIRS) to allow massive parallelization and time-of-flight (TOF) resolution, respectively. Both iDOS core technologies are established and poised for further innovative development and dissemination. TRD2 will further validate iDOS and advance use of diffuse optics in medicine.
TRD2 has four specific aims, illustrated in the image below. Aims 1 and 2 improve the technical performance of iDOS and Aim 2 expands their utility through prototyping and standardization. Aim 3 links iDOS with other approaches and Aim 4 integrates all into the intraprocedural workflow and database/cluster formation.
The iDOS research in this TRD seeks to accomplish the following deliverables:
- Low-cost (4 orders-of-magnitude cheaper than photon counting), high throughput, iDWS technology for scalable blood flow monitoring based on a multi-exposure CMOS approach
- A single fiber-based, multi-wavelength, picosecond TOF-resolved iNIRS platform, for quantitative measurements at sub-millimeter to centimeter spatial resolution
- High density iDWS arrays to monitor tissues at multiple sites, at greater depths, and with improved specificity
- Scanning and parallel iNIRS approaches for spatially resolved imaging
- Methods for standardization and integration of hemodynamic measures with other data streams to both reduce noise, motion artifacts, and systemic physiological interference and inform clinical decisions
Postdoctoral Scholars
- Dibbyan Mazumder, Ph.D., NYU Langone
- Santosh Aparanji, Ph.D., NYU Langone
- Mingjun Zhao, Ph.D., NYU Langone
Graduate Students
- Rishad Joarder
- Weitai Qian
- Shing-Jiuan Liu
Collaborative Projects
- Diffuse Optics for Pediatric Hydrocephalus Management
- Perioperative diffuse optical imaging of tissue blood flow and oxygenation for optimization of mastectomy skin flap viability
- Intravascular NIRF-IVUS imaging of inflammation-guided arterial therapy
- In utero Repair of Fetal Myelomeningocele
Service Projects
- Biomarker Signatures for Delayed Cerebral Ischemia and Outcome Following Subarachnoid Hemorrhage
- Brain-based Metrics for Prolonged Field Care (PFC) Tasks
- UC Davis Alzheimer’s Disease Research Center
- OMX-CV, A Novel Oxygen Delivery Biotherapeutic for Hemorrhagic Shock in the Battlefield
Facilities
- Srinivasan Laboratory in the Genome and Medical Sciences Facility at UC Davis
- Ghiasi Laboratory at College of Engineering
- UC Davis Biomedical Engineering Machine Shop: "TEAM LAB"
- Biomedical Engineering Rapid Prototyping Facility
- UC Davis Center for Molecular and Genomic Imaging (CMGI)
- Michael W. Chapman Emergency and Trauma Center
- UC Davis Large Animal Survival Surgical Facility “Centaur Facility”
Publications
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Zhao M, Zhou W, Aparanji S, Mazumder D, Srinivasan VJ. Interferometric diffusing wave spectroscopy imaging with an electronically variable time-of-flight filter. Optica. 2023 Jan 20;10(1):42-52. doi: 10.1364/OPTICA.472471.
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Zhou W, Zhao M, Srinivasan VJ. Interferometric diffuse optics: recent advances and future outlook. Neurophotonics. 2022 Oct;10(1):013502. PMID: 36284601. doi: 10.1117/1.NPh.10.1.013502.
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Ayaz H, Baker WB, Blaney G, Boas DA, Bortfeld H, Brady K, Brake J, Brigadoi S, Buckley EM, Carp SA, Cooper RJ, Cowdrick KR, Culver JP, Dan I, Dehghani H, et al. Optical imaging and spectroscopy for the study of the human brain: status report. Neurophotonics. 2022 Aug;9(S2):S24001. PMID: 36052058. doi: 10.1117/1.NPh.9.S2.S24001.
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Kholiqov O, Zhou W, Zhang T, Zhao M, Ghandiparsi S, Srinivasan VJ. Scanning interferometric near-infrared spectroscopy. Optics Letters. 2022 Jan 1;47(1):110-3. PMID: 34951892. doi: 10.1364/OL.443533.
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Zhou W, Zhao M, Kholiqov O, Srinivasan VJ. Multi-exposure interferometric diffusing wave spectroscopy. Optics Letters. 2021 Sep 15;46(18):4498-501. PMID: 34525031. doi: 10.1364/OL.427746.
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Kasap B, Vali K, Qian W, Hedriana HL, Wang A, Farmer DL, Ghiasi S. Towards Noninvasive Accurate Detection of Intrapartum Fetal Hypoxic Distress. In2021 IEEE 17th International Conference on Wearable and Implantable Body Sensor Networks (BSN) 2021 Jul 27 (pp. 1-4). IEEE. doi: 10.1109/BSN51625.2021.9507036.
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Kasap B, Vali K, Qian W, Chak WH, Vafi A, Saito N, Ghiasi S. Multi-Detector Heart Rate Extraction Method for Transabdominal Fetal Pulse Oximetry. In2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) 2021 Nov 1 (pp. 1072-1075). IEEE. PMID: 34891473. doi: 10.1109/EMBC46164.2021.9630946.
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Tian F, Hu J, Yang W. GEOMScope: Large Field‐of‐View 3D Lensless Microscopy with Low Computational Complexity. Laser & Photonics Reviews. 2021 Aug;15(8):2100072. PMID: 34539926. doi: 10.1002/lpor.202100072.
Presentations
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Kasap B, Vali K, Qian W, Mo L, Chithiwala ZH, Hedriana HL, Ghiasi S. Use of A Novel Transabdominal Fetal Pulse Oximeter (TFO) In Human Pregnancy: A Proof-of-Concept. American Journal of Obstetrics & Gynecology. 2023 Jan 1;228(1):S100. doi: 10.1016/j.ajog.2022.11.211.
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Qian W, Vali K, Kasap B, Pivetti CD, Theodorou CM, Kulubya ES, Yamashiro KJ, Wang A, Hedriana HL, Lee Farmer D, Ghiasi S. Continuous Transabdominal Fetal Pulse Oximetry (TFO) in Pregnant Ewe Models under Induced Fetal Hypoxia. American Journal of Obstetrics & Gynecology. 2023 Jan 1;228(1):S242-S3. doi: 10.1016/j.ajog.2022.11.441.
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Zhao M, Zhou W, Aparanji S, GhandiParsi S, Srinivasan VJ, editors. Parallel interferometric Diffusing Wave Spectroscopy (iDWS) with Time-of-Flight Discrimination. Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN); 2022 2022/04/24; Fort Lauderdale, Florida: Optica Publishing Group.
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Liu S-J, Ghiasi S, Yang W. Fiber-based frequency-modulated continuous-wave near-infrared spectroscopy for transabdominal fetal pulse oximetry: SPIE BIOS; 2022, San Francisco, California.