Patents

Patents Issued

  1. Sherlock BE, Yankelevich DR, Bec J, Marcu L. Fiber-based multimodal biophotonic imaging and spectroscopy system. U.S. patent US12569140B2. Issued 2026 Mar 10.

  2. Bec J, Marcu L. Catheter motor drive unit that facilitates combined optical coherence tomography and fluorescence-lifetime imaging. U.S. patent US12357163B2. Issued 2025 Jul 15.

  3. Zhou W, Kholiqov O, Srinivasan V. Interferometric technique for measuring cerebral blood flow using inexpensive CMOS sensors. U.S. patent US12507903B2. Issued 2025 Oct 21. 

  4. Ghiasi S, Fong D, Vali K, Kasap B, Qian W. Transabdominal fetal oximetry without explicit fetal signal extraction. U.S. patent US12446807B2. Issued 2025 Dec 30. 

  5. Zhou W, Kholiqov O, Srinivasan V. Interferometric technique for measuring cerebral blood flow using inexpensive CMOS sensors. U.S. patent US11980453B2. Issued 2024 May 14. 

  6. Ghiasi S, Fong D. Contextually aware fetal sensing in transabdominal fetal pulse oximetry. U.S. patent US12070312B2. Issued 2024 Aug 27. 

  7. Marcu L, Bec J, Yankelevich DR. Single catheter system that provides both intravascular ultrasound and fluorescence lifetime imaging. U.S. patent US11350907B2. Issued 2022 Jun 7.

Patent Applications

  1. Marcu L, Thrapp A, Bec J. Probes, systems, and methods for multimodal optical imaging. U.S. provisional patent application 64/118,766. Filed 2026 Jul 24. UC Case 2026-923-2.

  2. Kristen C, Marcu L, Thrapp A. Volumetric optical coherence tomography using a passively scanned probe. U.S. provisional patent application US64/072,612. Filed 2026 May 22. UC Case 2026-430.

  3. Marcu L, Sadegh C, Thrapp A. Optical coherence tomography and fluorescence lifetime imaging for endoscopic brain imaging and subsequent ablation. U.S. provisional patent application 64/157,504. Filed 2026 Sept 16. UC Case 2026-465.

  4. Ghiasi S, Saffarpour M, Qian W, Kasap Darbaz B, Joarder RR, Fowler R. Transabdominal fetal oximetry systems, methods, and media for non-invasive fetal metabolic assessment. U.S. patent application 19/657,680. Filed 2026 Apr.

  5. Bec J, Marcu L, Srinivasan V, Thrapp A, Samanta R. Hybrid optical measurement systems, devices, and methods. U.S. provisional patent application 63/962,050. Filed 2026 Jan 16. UC Case 2026-386-2.

  6. Strohmer T, Xu S, Ni Y, Broecker S. Method for unlearning content for large language models. U.S. provisional patent application 63/913,472. Filed 2025 Nov 7. UC Case 2026-380. 

  7. Qian W, Ghiasi S. Systems, methods, and media for source signal separation from non-invasively obtained mixed photoplethysmography signals using a machine learning model trained with a synthesized mixed photoplethysmography dataset. U.S. provisional patent application 63/926,042. Filed 2025 Nov 26. UC Case 2026-418-1 US.

  8. Lihe T, Ghiasi S. Systems, methods, and media for determining fetal photoplethysmography information from non-invasively obtained mixed photoplethysmography signals. U.S. provisional patent application 63/907,719. Filed 2025 Oct 29. UC Case 2026-414-1.

  9. Yang W, Srinivasan V, Liu SJ, Zhao M, Ghiasi S. Transabdominal measurement of oxygen saturation and/or blood flow index through multi-exposure time-of-flight filtered iDWS. U.S. provisional patent application 63/829,467. Filed 2025 June 24. and U.S. Patent Application 19/657,680. Filed 2026 Apr 24. UC Case 2025-574.

  10. Qi J, Huang B. High-resolution and low-cost positronium lifetime image reconstruction. U.S. provisional patent application 63/909,472. Filed 2025.

  11. Qi W, Yang L, Asma E, Kolthammer J, Qi J. Population-based data-driven gating based on clustering short-frame data features. U.S. patent application 19/017,229. Filed 2025.

  12. Tsai YJ, Qi W, Qi J, Yang L, Asma E, Kolthammer J. Method and apparatus for performing image enhancement using a neural network in a medical imaging system. U.S. patent application 19/016,764. Filed 2025.

  13. Bec J, Zhou X, Marcu L, Villiger M, Bouma B. Dual modality intravascular catheter system combining pulse-sampling fluorescence lifetime imaging and polarization-sensitive optical coherence tomography. U.S. provisional patent application 63/625,818. Filed 2024 Jan 26. UC Case 2024-558-2.

  14. Yang W, Liu SJ, Ghiasi S. Transabdominal fetal oximetry based on frequency-modulated continuous-wave near-infrared spectroscopy. U.S. patent application 18/249,714. Published 2024 Jan 25 as US20240023846A1.

  15. Marcu L, Bec J, Bloch O. Automatically controlling an integrated instrument. U.S. patent application 18/880,484. Filed 2023 Aug 29. Published 2025 Dec 25 as US20250387171. UC Case 2022-532-1.

  16. Bec J, Marcu L. Broadband, freeform focusing micro optics for side-viewing imaging catheters. U.S. patent application 18/086,462. Filed 2022 Dec 21. Published 2023 May 4 as US20230136729A1. Notice of allowance 2026 Apr 29. 

    International

  17. Saffarpour M, Ghiasi S. Deep harmonic finesse: signal separation in wearable systems with limited data. International patent application PCT/US2025/014661. Filed 2025.