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This presentation reports our recent progress on two-photon (2P) fiberscope technology and its potential applications. The ultracompact, lightweight fiberscope (Ø2.4mm, <1g) employs customized fiber to suppress nonlinear background and achieves a large field-of-view (500–600μm) using cascaded magnification micro-optics. Miniature deformable lenses provide focus tuning, while an opto-electrical commutator with real-time torque sensing and compensation enables twist-free operation. A simple apparatus can also be incorporated to offset excess head weight when needed. Together, these innovations greatly advance the utility of 2P fiberscopes for label-free optical histology and functional neuroimaging in freely-moving rodents.
Presenter
Johns Hopkins Univ. (United States)
Dr. Xingde Li is a Professor in the Department of Biomedical Engineering at Johns Hopkins University. His research centers on advanced biophotonics imaging technologies and their applications in both basic and translational research. He has published over 155 journal papers, which have been cited more than 24,000 times, with an H-index of 68. In addition to research, Dr. Li has served on many scientific society committees and held editorial roles as topical editor and associate editor for multiple journals. He is the lead founding EiC of BMEF, a Science Partner Journal. Dr. Li is a Fellow of OPTICA, SPIE, and AIMBE.