Event Date
Event Date
Rapid and accurate assessment of burn severity is critical for triage and treatment, requiring detection of both deep optical property changes and superficial biochemical alterations. We present a dual-modality system that integrates speckle-modulated interferometric near-infrared spectroscopy (iNIRS) and fluorescence lifetime imaging (FLIm) using a dual-clad fiber (DCF) probe. iNIRS illumination is delivered through the cladding and collected via the single-mode core to analyze optical properties, while FLIm excitation and emission are transmitted through the cladding to assess biochemical signals. A reversible DCF coupler enables signal separation. Validation with tissue phantoms showed that iNIRS detects burn-related differences, with non-healing burn models exhibiting a 20% longer decay (57 ps shift) in time-of-flight distributions compared to self-healing models. Simultaneous FLIm collagen-channel data (λ_ex = 355 nm, λ_em = 390 nm) was acquired with high signal-to-noise (~55 dB). These results demonstrate the potential of combined FLIm-iNIRS for non-invasive, rapid detection of complementary biomarkers to guide burn triage.
Presenter
National Ctr. for Interventional Biophotonic Technologies, UC Davis Health System (United States)
I am a researcher and engineer specializing in the development of advanced biophotonic technologies for medical imaging and diagnostics. My work focuses on the design and implementation of multimodal imaging systems, particularly those combining structural imaging modalities, such as optical coherence tomography (OCT), with fluorescence imaging (both label-free autofluorescence and exogenous).