Event Date
Event Date
This study presents a novel spatial augmentation system that integrates real-time fluorescence lifetime imaging (FLIm) with preoperative MRI navigation to enhance intraoperative guidance during brain tumor resection. A pulse-sampling FLIm probe was combined with the BrainLab Curve neuro-navigation platform via the OpenIGTLink protocol, with a custom Python interface ensuring synchronized data streams and real-time 3D visualization of FLIm signals on MRI models. Phantom testing confirmed a 180 ms latency between FLIm and tracking data. Intraoperative validation in a glioblastoma (GBM) case achieved the first real-time 3D fusion of FLIm and preoperative MRI in the operating room. Histopathological analysis confirmed the accuracy of FLIm-based tumor margin detection. This integrated system enables spatially resolved, real-time tissue characterization, offering a significant step forward in precision-guided neurosurgery.
Presenter
Univ. of California, Davis (United States)
Xuhui Liu currently works as a postdoc at Dr. Laura Marcu's Lab at UC Davis. His research focuses on the development of biophotonic instruments such as multi-model fluorescence lifetime instruments, FLIm microscopy, multi-spectral FLIm, FLIm-MRI Augmentation, Xuhui's research also focuses on near-infrared spectroscopy/imaging, diffuse speckle contrast analysis, diffuse correlation spectroscopy, and laser speckle contrast imaging.