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Event Date
We report the analysis conducted on 25 human coronary plaques, imaged using an integrated multispectral FLIm/polarization-sensitive OCT system, to study the optical features of high-risk oxidized lipids in atherosclerosis lesions. Imaging data were pixel-to-pixel registered with histology images. Current results from 4 arteries demonstrated a 118.4% decrease in the degree of depolarization gradient in lipid-rich regions. FLIm can distinguish oxidized lipids from PSOCT-identified lipid regions, as demonstrated by a 19.3% longer lifetime at macrophage foam cells (mFCs) accumulated regions. Although macrophage or lipid accumulation areas also exhibited prolonged lifetime by 23.3% and 6.04%, respectively, regions rich in only macrophages or only lipids demonstrated minimal change. Thus, we conclude that the increased lifetime is driven by oxidized lipids within mFCs. This preliminary study illustrates that integrating PSOCT and FLIm can help identify oxidized lipids in atherosclerotic plaques, potentially identifying plaques at a higher risk of rupture.
Presenter
Xiangping Ouyang
Univ. of California, Davis (United States)
Xiangping Ouyang is a Ph.D. student in Biomedical Engineering at the University of California, Davis, working under the guidance of Dr. Laura Marcu. Her current research focuses on biochemical markers detection associated with atherosclerotic plaque progression using a dual modality intravascular catheter system that integrates fluorescence lifetime imaging (FLIm) with polarization-sensitive optical coherence tomography (PSOCT). She received her undergraduate and master’s degrees in Computer Engineering at Washington University in St. Louis. Her research interests encompass optical coherence tomography, machine learning, and 3D image processing.